Anti-Aging Supplement Benefits of NAD+ 11-Complex AEON


Anti-Aging Supplement Benefits of NAD+ 11-Complex AEON

Scientists believe that aging is not a necessary side effect of life as once believed but rather an obstacle programmed into our DNA that we may soon be able to remove.

In the interim there is a lot of research in the field of gerontology and longevity that recently discovered several supplements that can help us to slow down and even reverse the aging process. The key to preventing aging and even reversing the aging process is therefore dependent on taking a combination of supplements that are proven scientifically to enhance longevity and of course to combine this with other aspects proven to enhance longevity e.g. exercise, fasting, good quality sleep, stress relief etc. 

It is this scientific research that led to the creation of AEON, an anti-aging supplement that contains a complex of 11 age defying supplements with NAD+ boosting characteristics and is considered by many to be the best anti-aging supplement to come out of North America. 


AEON, created by our company Perpetua.Life is an advanced longevity supplement that contains a full spectrum 11-compound complex. Below you can read all the ingredients contained in AEON 3.0. Each of the ingredients of AEON 3.0 and its significance in maintaining good health and its fight against aging will be explained below the listed ingredients.

Each dose consists of two easy to swallow capsules that contain: 

Nicotinamide DUO™ (as Mono and Riboside, NMN + NR) 500mg, Resveratrol (trans-resveratrol) 150mg, L-Theanine 100mg, Fisetin 100mg, Astragalus 100mg, Piperine 10mg, TMG 85mg, Spermidine 10mg, Epigallocatechin gallate (EGCG) 100mg, Quercetin 250mg. Other ingredients: Riboflavin 1mg, Vitamin B6 5mg, Vitamin B12 250mcg, Vegetable cellulose (capsule), Natural blue colouring (from red cabbage), Liposomal delivery matrix.

NOTE: AEON is independently tested by the Trade Commission for authenticity and contaminants. AEON is tested by an independent GLP compliant laboratory, accredited to ISO/IEC 17025:2017 to confirm it contains what is printed on the label, is free of more than 270 athletic banned substances, has no unsafe levels of contaminants & is manufactured in a GMP-certified facility.


Several of AEON's ingredients are NAD+ boosters e.g NR, NMN, Resveratrol, Quercetin, Fisetin etc. and for this reason we will start by explaining the role of NAD+ in the body.

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme that plays a critical role in various cellular processes. Its significance lies in its involvement in fundamental biochemical reactions that affect energy production, DNA repair, cell signaling, and overall cellular health. NAD+ has garnered significant attention, particularly in the field of aging research, due to its central role in these essential functions. Here are some key aspects of the significance of NAD+:

1. Energy Metabolism:

One of the primary functions of NAD+ is its role in energy metabolism. It serves as a cofactor in reactions that convert nutrients from food, such as glucose and fatty acids, into energy in the form of adenosine triphosphate (ATP) through processes like glycolysis and oxidative phosphorylation. NAD+ is crucial for transferring electrons during these metabolic reactions, allowing cells to efficiently generate energy.          

2. DNA Repair:

NAD+ is essential for DNA repair processes, which maintain the integrity of the genetic material within cells. Enzymes called poly(ADP-ribose) polymerases (PARPs), which require NAD+ as a substrate, are involved in DNA damage repair. They play a key role in detecting and repairing DNA strand breaks, helping to prevent mutations and maintain genomic stability.   

3. Cellular Signaling:

NAD+ also acts as a signaling molecule, particularly through its role in regulating sirtuins. Sirtuins are a family of proteins that are dependent on NAD+ for their activity. They are involved in various cellular processes, including gene expression, stress response, and longevity. Sirtuins play a role in modulating cellular processes to promote health and longevity.

4. Mitochondrial Function:

NAD+ is essential for the function of mitochondria, the "powerhouses" of the cell responsible for producing ATP and regulating cellular metabolism. NAD+ participates in critical reactions within the mitochondria, such as the citric acid cycle (Krebs cycle) and oxidative phosphorylation. These processes are essential for generating energy and maintaining cellular health.

5. Aging and Longevity:

NAD+ levels tend to decline with age, which has led to a growing interest in its role in the aging process. Researchers like Dr. David Sinclair have proposed that declining NAD+ levels contribute to cellular dysfunction, DNA damage accumulation, and the development of age-related diseases. Strategies to boost NAD+ levels have been investigated as potential interventions to promote healthier aging and extend lifespan.

6. Healthspan Promotion:

Maintaining adequate NAD+ levels is thought to support healthspan, the period of life spent in good health and without debilitating diseases. By maintaining cellular functions such as energy production, DNA repair, and stress response, NAD+ contributes to overall well-being and functional longevity.

The significance of NAD+ reaches across multiple areas of cellular biology, energy regulation, and health. Its role in diverse cellular processes underscores its importance for maintaining the proper function of cells and tissues.


NAD+ boosters are compounds that are believed to increase the levels of nicotinamide adenine dinucleotide (NAD+) in the body. These compounds are of interest in the field of aging research due to the potential role of NAD+ in promoting cellular health and longevity. Some NAD+ boosters include:

1. Nicotinamide Riboside (NR):

NR is a precursor to NAD+ and is converted into NAD+ through a series of enzymatic reactions. It is found in trace amounts in certain foods like milk. NR has gained attention for its potential to increase NAD+ levels and support cellular functions.

2. Nicotinamide Mononucleotide (NMN):

NMN is another precursor to NAD+ and is also converted into NAD+ in cells. It's found in various foods like fruits and vegetables. NMN has been studied for its potential to raise NAD+ levels and potentially offer health benefits.

3. Resveratrol:

Resveratrol is a compound found in red wine, grapes, and some berries. While it's primarily known for its potential antioxidant properties, it has also been suggested to activate certain sirtuin enzymes, which are dependent on NAD+.

4. Quercetin:

Quercetin is a flavonoid found in various plant foods like onions, apples, and berries. It has been explored for its potential to boost NAD+ levels and support cellular health.

5. Fisetin:

Fisetin is another flavonoid found in fruits like strawberries and apples. Like other compounds, it's thought to influence NAD+ levels and cellular function.



L-Theanine is an amino acid found primarily in tea leaves, particularly in green tea (Camellia sinensis). It is known for its potential calming and relaxation effects, making it a popular dietary supplement.

L-Theanine has been studied for its various physiological and psychological effects including relaxation and stress reduction, enhancement of cognitive function, improvement of sleep quality, neuroprotection, enhanced blood pressure regulation, antioxidant properties and mood enhancement.


Astragalus (Astragalus membranaceus) is a traditional herb used in Chinese medicine for centuries. It is known for its potential health benefits and has been studied for various medicinal properties.

Some of its properties include:

1. Immune system support

2. Adaptogenic effects that helps the body to adapt to stress

3. Anti-inflammatory properties

4. Antioxidant effects

5. Heart health by improving blood flow and reducing blood pressure

6. Improve insulin sensitivity and blood sugar levels 

7. Protecting the liver from toxins and certain medications

8. Protect the kidneys from damage caused by various factors

9. Cancer support: Some research indicates that astragalus might have potential anticancer effects by modulating the immune system and inhibiting tumor growth. However, this area requires further investigation. 


Piperine is the active compound found in black pepper (Piper nigrum) that gives it its characteristic spicy flavor. Beyond being a culinary spice, piperine has been studied for its potential health benefits. Here are some of the potential benefits associated with piperine consumption: 

1. Enhancement of nutrient absorption

2. Anti-inflammatory effects

3. Antioxidant activity

4. Digestive health: Piperine may support digestive health by increasing the secretion of digestive enzymes.

5. Weight management

6. Brain health: Piperine may have potential benefits for brain health. It has been studied for its possible role in enhancing cognitive function, memory, and mood regulation.

7. Pain relief

8. Blood sugar regulation

9. Antimicrobial properties

10.  Cancer Prevention: Preliminary research has indicated that piperine might have anticancer effects, particularly in terms of inhibiting the growth and spread of cancer cells. However, more research is needed in this area.


Trimethylglycine (TMG), or betaine, is made up of the amino acid glycine with three methyl groups that are attached to it. TMG supplement can help lower homocysteine levels, improve athletic performance, has a protective effect on the liver, has anti-inflammatory properties, help prevent cancer, fight depression, ease autism symptoms, and improve cognitive function. 

TMG is a methyl donor, meaning it can provide methyl groups for various biochemical reactions in the body. Methylation is essential for a range of processes, including DNA synthesis, detoxification, and gene expression.


Spermidine is a naturally occurring polyamine compound found in cells and various foods. It has gained attention in recent years due to its potential health benefits:

1.  Autophagy Enhancement: One of the most researched and prominent benefits of spermidine is its role in promoting autophagy, a cellular process that helps remove damaged cellular components and recycle them for energy. Autophagy is believed to play a role in maintaining cellular health, delaying the aging process, and reducing the risk of various age-related diseases.

2. Cardiovascular health

3.  Longevity: Spermidine has been investigated for its potential to extend lifespan. Research in animal models has shown that supplementing with spermidine can increase lifespan in certain organisms.

4. Neuroprotection

5.  Cognitive Function: Due to its potential neuroprotective properties, spermidine might also play a role in supporting cognitive function and memory. However, more research is needed to establish a clear link between spermidine supplementation and cognitive benefits in humans.

6. Immune system support

7.  Cellular Health: Spermidine is involved in various cellular processes, including DNA stabilisation and protein synthesis. It plays a role in maintaining overall cellular health and function.

8.  Hair and Skin Health: Spermidine is found in some hair and skincare products due to its potential to promote hair growth and improve the quality of skin.


Epigallocatechin gallate (EGCG) is a polyphenol compound found in green tea and is considered one of the most abundant and biologically active compounds in tea leaves. It has been studied extensively for its potential health benefits. Here are some of the potential benefits of EGCG:

1.  Antioxidant properties

2.  Heart health

3.  Weight management

4.  Brain health

5.  Cancer Prevention: EGCG has attracted attention for its potential anti-cancer properties. It may inhibit the growth of cancer cells, promote apoptosis (programmed cell death) in cancer cells, and block the formation of new blood vessels that supply tumors. However, while promising, more research is needed to fully understand its role in cancer prevention and treatment.

6.  Diabetes management

7.  Anti-Inflammatory effects

8.  Skin Health: Topical applications of EGCG have been explored for their potential benefits on skin health. EGCG's antioxidant and anti-inflammatory properties might help protect the skin from damage caused by UV radiation and environmental pollutants.

9.  Liver health


Quercetin is a flavonoid, a type of plant compound found in a variety of foods, particularly fruits, vegetables, and certain beverages like tea. It is known for its antioxidant and anti-inflammatory properties. Quercetin has been studied for its potential health benefits, and here are some of the key ones:

1. Antioxidant activity 

2. Anti-Inflammatory effects

3. Immune system support

4. Improves heart health

5. Allergy relief

6. Improves cognitive function

7. Antiviral properties: Quercetin has been investigated for its potential antiviral effects. It might inhibit the replication of certain viruses and could play a role in supporting the body's defense against viral infections.

8.  Cancer prevention: Quercetin's antioxidant and anti-inflammatory properties may contribute to its potential anti-cancer effects. Some studies have suggested that quercetin could inhibit the growth of cancer cells and interfere with cancer-promoting processes.

9. Skin health: Due to its antioxidant and anti-inflammatory properties, quercetin might have benefits for skin health. It could help protect the skin from UV damage and reduce inflammation associated with skin conditions.

10. Blood sugar regulation: Quercetin may help regulate blood sugar levels and improve insulin sensitivity. This could be beneficial for individuals with diabetes or those at risk of developing diabetes.

Vitamin B complex including Riboflavin (vitamin B2), vitamin B6 and vitamin B12:

The benefits of the individual B vitamins above are extensive and we encourage you to do more detailed research on the benefits of the above B vitamins. We will simply provide a short summary below:

Riboflavin, also known as vitamin B2, is an essential water-soluble vitamin that plays a crucial role in various bodily functions. It's involved in energy metabolism, cellular growth, and the maintenance of overall health.

Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that plays a critical role in various physiological processes within the body. It's involved in over 100 enzymatic reactions, making it essential for overall health.

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a vital role in various bodily functions. It's essential for maintaining the health of nerve cells, producing DNA and RNA, and supporting the normal function of red blood cells.


The 3.0 is head and shoulders above the previous version. All the ingredients are encased in a Liposomal delivery matrix (phospholipids) that bypasses stomach acids. This as well as the addition of Piperine increases absorption by 300-500% (especially of Resveratrol).

The B vitamins aid in absorption/methylation, and are considered co-factors of compounds like TMG and NMN. We added TMG, and Spermidine to the new 3.0 formulation (which are both part of Dr. Sinclair’s daily anti-aging protocol).

Based on current research the medical board decided to pull these ingredients (CoQ10, Curcumin, Collagen, Crocin) from version 2.0  since they considered the dosing suboptimal, while adding TMG and Spermidine adheres more closely to Dr. Sinclair's protocol. In addition Piperine was added to increase absorption and NR was added to NMN to form Nicotinamide Duo.

We also got rid of less desirable fillers and binders that used to be contained in AEON 2.0. Silicon dioxide and magnesium stearate has now been removed from the new AEON 3.0 formulation.

The new formula focuses on activating longevity genes (SIRT1, FOXO’s), and fighting senescent cells, more effectively. The dosages have been adjusted based on the new higher absorption rates, and best/latest research.


You can navigate to the AEON 3.0 product page on our website. Next to each ingredient explained in great detail on the product page you will see numbers linked like this - (2223). If you click on those numbers it will take you to the various scientific studies on those particular ingredients.


AEON can be obtained directly from our Perpetua Life® UK  website or can be obtained from Ebay. Regardless whether you buy directly from our website or directly from Ebay, it will make no difference in regards to the shipping time.

Buying directly from our website however will allow you to sign up to a monthly subscription which will entitle you to a 20% discount on AEON. Further to this, should you decide to order a year supply (x12 bottles of AEON) a discount of 30% will automatically apply to your cart. These discounts are not available should you choose to buy AEON directly from Ebay. 


You are welcome to visit our FAQ. All of the questions you may have about AEON will be answered there. Should you have any additional questions then please contact us here:


These statements and text have not been evaluated by the European Food Safety (EFSA) or the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease or health condition.





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